For example, you can access AG3 backend in browser via this link :
https://jerry:44354/sap/bc/gui/sap/its/webgui
The initial screen looks like below, almost exactly the same as what you see in SAPGUI.
All short key like, F3, F8, Ctrl+F3 are still available in browser.
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The limitation is that ABAP code highlight is not supported in WebGUI. As a result, if you need to write ABAP code, you’d better to still use SAPGUI or ABAP in Eclipse.
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But if your daily work just consists of light-weight operations such as going through customizing via SPRO, checking table content in SE16, or check dumps in ST22, you don’t need SAPGUI at all. See below screenshots for example:
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