报错信息：

./sqlplus: error while loading shared libraries: libsqlplus.so: cannot open shared object file: No such file or directory

解决方法：

[oracle@localhost dbhome_2]$ ./sqlplus
./sqlplus: error while loading shared libraries: libsqlplus.so: cannot open shared object file: No such file or directory

# 修改环境变量参数：
[oracle@localhost ~]$ cat .bash_profile
# .bash_profile

# Get the aliases and functions
if [ -f ~/.bashrc ]; then
        . ~/.bashrc
fi

# User specific environment and startup programs
export ORACLE_BASE=/u01/app/oracle
export ORACLE_HOME=/u01/app/oracle/product/11.2.0/dbhome_2
export LD_LIBRARY_PATH=$ORACLE_HOME/lib
export  LD_LIBRARY_PATH=$ORACLE_HOME:$LD_LIBRARY_PATH
PATH=$PATH:$HOME/bin:$ORACLE_HOME
export PATH

# 修改环境变量之后，恢复正常。
[oracle@localhost ~]$ sqlplus /nolog
SQL*Plus: Release 11.2.0.1.0 Production on Thu Nov 22 22:39:24 2018
Copyright (c) 1982, 2009, Oracle.  All rights reserved.
SQL>

参考文件：
SQL*Plus Fails with Loading libsqlplus.so Running From a New 11g Client Install (文档 ID 1206898.1)