npm i express npm ERR! syscall open

PS D:\xxx> npm i express
npm ERR! syscall open
npm ERR! path E:xxx
npm ERR! Error: EPERM: operation not permitted, open 'E:\xxx
npm ERR! [Error: EPERM: operation not permitted, open 'E:\xxx
npm ERR! errno: -4048,
npm ERR! code: ‘EPERM’,
npm ERR! syscall: ‘open’,
npm ERR! path: xxx
npm ERR! requiredBy: ‘.’
npm ERR! }
npm ERR!
npm ERR! The operation was rejected by your operating system.
npm ERR! It’s possible that the file was already in use (by a text editor or an
npm ERR! or that you lack permissions to access it.
npm ERR! If you believe this might be a permissions issue, please double-check
npm ERR! permissions of the file and its containing directories, or try running
npm ERR! the command again as root/Administrator.
npm ERR! You can rerun the command with --loglevel=verbose to see the logs in