andoird 5.0以上真机调试报错。?报错

android studio用数据线真机调试，5.0一下的版本一切正常。5.0开始就会报错，居然报ClassNotFoundException，我也是无语了。但是如果在5.0一下run之后生成的apk包可以在任何版本安装也不会报错。是不是5.0开始调试有一些特别的地方，大家有没有遇到过？求指点迷津

报错日志大致如下：其中xxx...用于隐藏真实项目包信息

 E/AndroidRuntime: FATAL EXCEPTION: main
 Process: com.xxx.xxxxx, PID: 22797
 java.lang.RuntimeException: Unable to instantiate activity ComponentInfo{com.xxx.xxxxx/com.xxx.xxxx.reserve.XxxActivity}: java.lang.ClassNotFoundException: Didn't find class "com.xxx.xxxx.reserve.XxxActivity" on path: DexPathList[[zip file "/data/app/com.xxx.xxxxx-2/base.apk"],nativeLibraryDirectories=[/data/app/com.xxx.xxxxx-2/lib/arm, /vendor/lib, /system/lib]]
 at android.app.ActivityThread.performLaunchActivity(ActivityThread.java:2241)
 at android.app.ActivityThread.handleLaunchActivity(ActivityThread.java:2392)
 at android.app.ActivityThread.access$800(ActivityThread.java:154)
 at android.app.ActivityThread$H.handleMessage(ActivityThread.java:1306)
 at android.os.Handler.dispatchMessage(Handler.java:102)
 at android.os.Looper.loop(Looper.java:135)
 at android.app.ActivityThread.main(ActivityThread.java:5275)
 at java.lang.reflect.Method.invoke(Native Method)
 at java.lang.reflect.Method.invoke(Method.java:372)
 at com.android.internal.os.ZygoteInit$MethodAndArgsCaller.run(ZygoteInit.java:909)
 at com.android.internal.os.ZygoteInit.main(ZygoteInit.java:704)
  Caused by: java.lang.ClassNotFoundException: Didn't find class "com.xxx.xxxx.reserve.XxxActivity" on path: DexPathList[[zip file "/data/app/com.xxx.xxxxx-2/base.apk"],nativeLibraryDirectories=[/data/app/com.xxx.xxxxx-2/lib/arm, /vendor/lib, /system/lib]]
 at dalvik.system.BaseDexClassLoader.findClass(BaseDexClassLoader.java:56)
 at java.lang.ClassLoader.loadClass(ClassLoader.java:511)
 at java.lang.ClassLoader.loadClass(ClassLoader.java:469)
 at android.app.Instrumentation.newActivity(Instrumentation.java:1066)
 at android.app.ActivityThread.performLaunchActivity(ActivityThread.java:2231)
 at android.app.ActivityThread.handleLaunchActivity(ActivityThread.java:2392)?
 at android.app.ActivityThread.access$800(ActivityThread.java:154)?
 at android.app.ActivityThread$H.handleMessage(ActivityThread.java:1306)?
 at android.os.Handler.dispatchMessage(Handler.java:102)?
 at android.os.Looper.loop(Looper.java:135)?
 at android.app.ActivityThread.main(ActivityThread.java:5275)?
 at java.lang.reflect.Method.invoke(Native Method)?
 at java.lang.reflect.Method.invoke(Method.java:372)?
 at com.android.internal.os.ZygoteInit$MethodAndArgsCaller.run(ZygoteInit.java:909)?
 at com.android.internal.os.ZygoteInit.main(ZygoteInit.java:704)?
Suppressed: java.lang.ClassNotFoundException: Didn't find class "com.xxx.xxxx.reserve.XxxActivity" on path: DexPathList[[zip file "/data/data/com.xxx.xxxxx/app_curRes/BaiduNaviSDK_3.1.1.jar"],nativeLibraryDirectories=[/vendor/lib, /system/lib]]
 at dalvik.system.BaseDexClassLoader.findClass(BaseDexClassLoader.java:56)
 at java.lang.ClassLoader.loadClass(ClassLoader.java:511)
 at java.lang.ClassLoader.loadClass(ClassLoader.java:504)
... 13 more
Suppressed: java.lang.ClassNotFoundException: com.xxx.xxxx.reserve.XxxActivity
 at java.lang.Class.classForName(Native Method)
 at java.lang.BootClassLoader.findClass(ClassLoader.java:781)
 at java.lang.BootClassLoader.loadClass(ClassLoader.java:841)
 at java.lang.ClassLoader.loadClass(ClassLoader.java:504)
... 14 more
  Caused by: java.lang.NoClassDefFoundError: Class not found using the boot class loader; no stack available