使用python set可以使程序更简洁
mylist = ['abc123', 'def456', 'ghi789','ghi123',"123"]

sub = ['123','456']

print(list(set(mylist)-set(sub)))

mylist = ['abc123', 'def456', 'ghi789','ghi123']
sub = ['123','456']
new_list = []

先确定正常的写法

for my_str in mylist:

for sub_str in sub:
    if sub_str in my_str:
        new_list.append(my_str)

print new_list

然后在理解这颗语法糖

print [j for i in range(5) for j in range(i)]

最后改写下

print [my_str for my_str in mylist for sub_str in sub if sub_str in my_str]

你需要

mylist = ['abc123', 'def456', 'ghi789','ghi123']
sub = ['123','456']

print ([i for i in mylist for j in sub if j in i])
输出：

['abc123', 'def456', 'ghi123']