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⛄ 内容介绍
Monoamine oxidase A (MAOA) is a mitochondrial enzyme that inactivates neurotransmitters of the monoamine family such as dopamine, serotonin, and norepinephrine. MAOA and MAOB are encoded by separate genes on the X chromosome and share 70% amino acid similarity. This chapter presents a study in which a considerable increase was observed in the amount of serotonin in MAOA–/– pups, with a return to close to normal levels in older mice. Brain and liver MAOA activity was abolished in these mice. Mutant mice lacked the characteristic barrel-like clustering of layer IV neurons in the primary somatosensory cortex. MAOA–/– mice displayed a wide array of behavioral abnormalities from birth through maturity. Increased male aggessiveness and increased male–male wounding were also observed. The results of this chapter show that MAOA controls the amount of serotonin and norepinephrine in neurons, and may be linked to aggression.
⛄ 部分代码
%__________________________________________________________________ %
% Archive-based Multi-Objective %
% Arithmetic Optimization Algorithm (MAOA) %
% %
% %
% Developed in MATLAB R2022a (MacOs) %
% %
% Author and programmer %
% --------------------------------- %
% Nima Khodadadi (蕵鈥渴� %
% e-Mail %
% --------------------------------- %
% nkhod002@fiu.edu %
% %
% Homepage %
% --------------------------------- %
% %
% %
% %
% %
%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%
% ----------------------------------------------------------------------- %
close all;
clc;
% format long g
% Initial parameters of the MAOA algorithm
for j=8
max_iter=100;
Pop=100;
ArchiveMaxSize=100;
nvar=30;
obj_no=2;
method=3;
Archive_F1=load(sprintf('P%d.txt',j));
mkdir (sprintf('P%d',j))
%-------------------------- MAOA -----------------------------------------
for i=1 % Numbver of independent runs
[Archive_F]=MAOA(max_iter,ArchiveMaxSize,Pop,nvar,method,j);
if numel(Archive_F')==2
continue
end
Archive_F=Archive_F';
if obj_no==2
plot(Archive_F1(:,1),Archive_F1(:,2),'Color','g','LineWidth',4);
hold on
plot(Archive_F(:,1),Archive_F(:,2),'ro','LineWidth',1,...
'MarkerEdgeColor','b',...
'MarkerFaceColor','r',...
'Marker','o',...
'MarkerSize',10);
legend('True PF','Obtained PF');
title(sprintf('MAOA FOR P%d PROBLEM',j));
xlabel('obj_1');
ylabel('obj_2');
hold off
end
if obj_no==3
plot3(Archive_F1(:,1),Archive_F1(:,2),Archive_F1(:,3),'Color','g','LineWidth',1);
hold on
plot3(Archive_F(:,1),Archive_F(:,2),Archive_F(:,3),'ro','LineWidth',1,...
'MarkerEdgeColor','b',...
'MarkerFaceColor','r',...
'Marker','o',...
'MarkerSize',10);
legend('True PF','Obtained PF');
title(sprintf('MAOA FOR P%d PROBLEM',j));
xlabel('obj_1');
ylabel('obj_2');
zlabel('obj_3');
hold off
end
savefig(sprintf('P%d/fig_%d.fig',j,i));
end
save(sprintf('P%d/result_P%d.mat',j,j));
end
⛄ 运行结果
⛄ 参考文献
[1] Mak T W , Penninger J , Roder J , et al. . MAOA[J]. The Gene Knockout FactsBook, 1998:705-706.
